PD-HF: A Trial of Peritoneal Dialysis in Patients With Severe Heart Failure and Chronic Kidney Di… (NCT02708407) | Clinical Trial Compass
TerminatedNot Applicable
PD-HF: A Trial of Peritoneal Dialysis in Patients With Severe Heart Failure and Chronic Kidney Disease
Stopped: Inability to recruit adequate number of participants
United Kingdom11 participantsStarted 2016-01
Plain-language summary
This trial is to establish whether ultrafiltration by peritoneal dialysis is a clinically effective treatment for patients with severe heart failure and moderate chronic kidney disease, thus improving quality of life and symptoms.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Severe heart failure (NYHA grade III or IV)
* Chronic kidney disease stage 3-4
* Fluid overload resistant to diuretics OR hospital admission for HF in last 6 months
* Left ventricular ejection fraction ≤40% in last 2 years (moderate/severe)
* Using optimal HF medication for ≥ 4 weeks including ACE-inhibitor (angiotensin-converting-enzyme inhibitor) OR angiotensin receptor blocker AND aldosterone antagonist AND beta-blocker unless intolerant and without dose change for ≥ 4 weeks
* Appropriately screened for revascularization and/or cardiac resynchronization therapy if clinically indicated.
Exclusion Criteria:
* Does not wish to participate
* Mental incapacity to consent
* CKD stage 5
* Normal renal excretory function
* Haemodynamically significant valvular disease amenable to surgery
* Cardiac or renal transplantation
* Considered by the investigator to unsuitable for PD due to previous abdominal surgeries, peritonitis, social circumstances or other reason
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before it finished — can you help me understand why it was stopped early, and whether that affects how useful its findings would be for someone in my situation?
2The main thing this trial was measuring was whether patients could walk 25 metres more after treatment — given that my heart failure and kidney disease may already limit my mobility, is a 25-metre improvement a meaningful goal in my case?
3Since this trial was testing peritoneal dialysis specifically for heart failure alongside chronic kidney disease, does that combination apply to my current stage of both conditions, and is peritoneal dialysis even something my care team would consider for me?
4Because the trial is listed as Phase NA and has been terminated, is there other completed or ongoing research on peritoneal dialysis for heart failure that might give us more reliable safety and benefit data to go on?
5Given that this trial was stopped and may not have produced full results, would standard treatments for my heart failure and kidney disease be a more evidence-backed path to discuss right now before considering something experimental?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
The primary end-point is a change of 25 metres walked