Rejuvenation of Premature Ovarian Failure With Stem Cells

Inclusion Criteria * Able to understand and communicate in English language * Signed and dated informed consent * Female over the age of 18 * Diagnosis of premature ovarian insufficiency: At least two menopausal FSH levels (≥ 40 IU/L) and/or Primary or secondary amenorrhea at least for 3-6 months OR Diagnosis of low ovarian reserve defined as: AMH \< \_0.42 ng/ML \& FSH \>20 IU/L, and/or failure of prior attempts of assisted reproductive techniques due to limited ovarian response (poor responder). * Normal karyotype 46, XX. * Presence of at least one ovary * Acceptable uterine anatomy (by any clinically and/or imaging acceptable methods) * Normal thyroid function as evidence by normal serum Thyroid Stimulating Hormone (TSH) levels. * Agree to report any pregnancy to the research staff immediately. * Willing and able to comply with study requirements and follow up instructions. * No other causes of female infertility in the subject If subject is planning to pursue pregnancy: Presence of at least unilateral tubal patency (with any clinically acceptable methods). Exclusion Criteria * Unable to understand and communicate in English language * Currently pregnant or breast-feeding * Has a history of, or evidence of current gynecologic malignancy within the past three years * Presence of adnexal masses indicating the need for further evaluation * Major mental health disorder that precludes participation in the study * Active substance abuse or dependence * Unfit or unwilling to …