Adults with degenerative meniscal tear receiving arthroscopic surgical management or knee drainage (arthrocentesis) +/- intra-articular steroid injection will be recruited to this non-interventional cohort study. The aim is to investigate whether measurement of an individual's synovial fluid biomarker response to a degenerative meniscal tear with symptoms predicts symptomatic and functional outcome suggestive of osteoarthritis (OA) of the knee.
Who can participate
Age range30 Years – 60 Years
SexALL
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Inclusion criteria
✓. Male or female aged 30-60 years.
✓. Participant able and willing to give informed consent.
✓. Clinical assessment demonstrates mechanical symptoms suggestive of meniscal pathology (focal knee pain +/- 1 or more of: catching/locking, giving way, focal joint-line tenderness, effusion, McMurray's positive) within last 12 months.
✓. Evidence on clinical MRI knee of meniscal tear.
✓. Participant is either in secondary care or has the potential to be referred to secondary care due to severity of symptoms.
✓. Patient has failed conservative therapy and elected for surgical arthroscopic treatment, or is due knee drainage/injection for clinical reasons.
✓. Competency of the English language to complete questionnaires independently.
Exclusion criteria
✕. Pre-existing advanced radiographic OA (KL grade 3-4) of index knee at baseline.
✕. Evidence of anterior cruciate ligament rupture, or more extensive soft tissue injury.
✕. History of an acute knee injury (within 12 weeks), or acutely locked knee
✕. Known history of inflammatory/septic arthritis of index knee.
✕. Knee replacement or other non-arthroscopic knee surgery (e.g. high tibial osteotomy) - previous or planned within 1 year of study start.
What they're measuring
1
Knee Injury and Osteoarthritis Outcomes Score (KOOS)-4