Left Atrial Appendage Closure With SentreHeart Lariat® Device

Inclusion Criteria: * Patients aged ≥18 years * Patients able and willing to provide informed consent * Documentation of atrial fibrillation or atrial flutter * Clinical decision by the subject's physician that the patient is at risk for embolic stroke, and oral anticoagulant medications (OAC) is contraindicated * Hypertension, Abnormal renal and hepatic function, Stroke, Bleeding tendency/predisposition, Labile International Normalized Ratios (INRs) on warfarin (HAS-BLED) score \> 3 * Congestive Heart Failure (CHF), Hypertension, Age \>65, Diabetes Mellitus, Stroke or Transient Ischemic Attack (TIA), Vascular Disease, Age \>75, Sex Category (CHADS2-VASC) score \>3, OR CHADS2-VASC of 2 if physician provides justification for procedure * Anatomy favorable for deployment of the SentreHeart Lariat® Exclusion Criteria: * Medically unable to provide informed consent * Previous cardiothoracic surgery * Patient is a candidate for catheter or surgical ablation * Need for concomitant cardiac surgery procedure * Thrombus in the left atrial appendage or left atrium * Pregnancy