CompletedNot Applicable

Air Pollution Study: The Effect of Ozone on the Lung

United States135 participantsStarted 2016-02

Plain-language summary

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy men and women Exclusion Criteria: * Cardiovascular disease * Respiratory disease * Diabetes * Pregnancy * HIV infection * History of smoking within the last 5 years * Daily use of antioxidant supplements (e.g., Vitamin C/E, selenium, beta-carotene, lycopene, lutein, zeaxanthin, or ginkgo biloba) * Orthopedic or rheumatological conditions that would interfere with cycle use

What they're measuring

Concentrations of M1 and M2 Macrophages in the Sputum 24 Hours After Exposure.

Timeframe: 24 hours after exposure.

Concentrations of M1 and M2 Macrophages in the Sputum 48 Hours After Exposure.

Timeframe: 48 hours after exposure

Concentrations of M1 and M2 Macrophages in the Sputum 72 Hours After Exposure.

Timeframe: 72 hours after exposure.

Trial details

NCT IDNCT02673775

SponsorRutgers, The State University of New Jersey

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06-07

Results submitted2023-07-17

View on ClinicalTrials.gov More Air Pollution trials