Periodontal Phenotype Study (Tooth Extraction)

Inclusion Criteria: * Age: 18 to 75 years * Gender: No restriction * Subjects must require a single-rooted tooth extraction (Tooth deemed as periodontally and/or restoratively hopeless) in the maxillary anterior region (first premolar to first premolar) * Subjects must be able and willing to follow instructions related to the study procedures * Subjects must have read, understood and signed an informed consent form Exclusion Criteria: * More than 1 mm of recession present on the tooth planned for extraction and inclusion in the study * Reported allergy or hypersensitivity to any of the products to be used in the study * Severe hematologic disorders, such as hemophilia or leukemia * Active severe infectious diseases that may compromise normal healing * Liver or kidney dysfunction/failure * Currently under cancer treatment or within 18 months from completion of radio- or chemotherapy * Subjects who have a long-term history of oral bisphosphonate use (i.e. 10 years or more) * Subjects with a history of IV bisphosphonates * Subjects with uncontrolled diabetes, defined as Hba1c \> 7.0 * Subjects with severe metabolic bone diseases, such as Paget's disease of bone, will be excluded * Pregnant women or nursing mothers * Heavy smokers: Subjects who have smoked \>10 cigarettes per day within 6 months of study onset * Concomitant medications: Subjects on concomitant drug therapy for systemic conditions that may affect the outcomes of the study will not be included in the study. NOT…