Blood Brain Flow and Exercise (NCT02653638) | Clinical Trial Compass
CompletedEarly Phase 1
Blood Brain Flow and Exercise
United States80 participantsStarted 2016-06
Plain-language summary
Cerebral vasodilator responses to CO2 will be measured in young healthy adults, healthy sedentary older adults, and healthy exercise trained older adults. This variable will be examined before and after administering the cyclooxygenase inhibitor indomethacin, which has been shown to blunt cerebral vasodilator responses. In addition, the investigators will examine these counter-regulatory hemodynamic mechanisms to hypoperfusion caused by indomethacin.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Young subjects between 18-35 years old
* Older subjects between 55-75 years old
* Nonsmokers
* Physically active (exercise more than 3 times per week for at least 30 minutes)
* Sedentary (no formal exercise over 1 hour per week).
Exclusion Criteria:
* Outside of the specified age range
* Present with history or evidence of hepatic, renal, or hematological disease; peripheral vascular disease; stroke/neurovascular disease; diabetes; hypertension
* Take medications that indicate hepatic, renal, hematological disease; cardiovascular disease, including hypertension; stroke/neurovascular disease; and diabetes
* Body mass index \>34 kg/m2
* Take physician-prescribed medications that may interact with indomethacin: 1) cardiovascular drugs (e.g. angiotensin-converting-enzyme inhibitor (ACE inhibitors), angiotensin II receptor blockers (ARB's), Diuretics); 2) drugs that would increase bleeding risk (e.g. warfarin, heparin, clopidogrel, rivaroxaban, other NSAIDs); or 3) drugs associated with increased renal toxicity (e.g. cyclosporin, tacrolimus)
* Vulnerable populations (i.e. pregnant women, prisoners, individuals lacking capacity to consent, etc.)