TerminatedNot Applicable

Serial, Non-invasive Analysis of Exhaled Breath Condensate in Ventilated Trauma Patients

Stopped: We did not have the funding to complete the study enrollment.

United States110 participantsStarted 2016-01

Plain-language summary

To determine if the analysis of exhaled breath condensate correlates with the development \& resolution of pneumonia.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 or older * Admitted to the Vanderbilt Trauma (TICU) and Surgical Intensive Care Units (SICU) * Mechanically ventilated for ≥2 successive days (without planned extubation within 24 hours of enrollment) Exclusion Criteria: * Less than 18 years of age * Expected survival less than 24 hours * Anticipated extubation within 24 hours of enrollment * Conditions limiting the subject's ability to tolerate collection of lavage specimens, including: FIO2 \> 80%; PEEP \> 16 cmH2O; Intracranial pressure \>20 cmH2O; Tracheal or mucosal bleeding; Platelet count \< 20,000 cells/uL; INR \> 2.0 * Known prisoners * Pneumonia diagnosis at the time of ICU admission

What they're measuring

The number of patients with a positive association between the exhaled breath condensate fluid and BAL fluid in in patients suspected of pneumonia.

Timeframe: enrollment to hospital day 15

The per cent of positive correlation for the development & resolution of pneumonia based on changes in bacteria found in the exhaled breath condensate.

Timeframe: enrollment to hospital day 15

Trial details

NCT IDNCT02652247

SponsorVanderbilt University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06

View on ClinicalTrials.gov More Ventilator Associated Pneumonia (VAP) trials