Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy? (NCT02652143) | Clinical Trial Compass
TerminatedNot Applicable
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
Stopped: Terminated due to difficult recruitment
Spain35 participantsStarted 2016-01
Plain-language summary
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
Who can participate
Age range
18 Years – 38 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Signed Informed Consent by the subject and her partner
* Women, aged between 18 and 38 years (up to 38th birthday)
* ≤ 2 previous stimulation cycles
* Routinely measured hormonal levels within normal range (i.e. FSH, LH, E2, PRL)
* No uterine or ovarian anatomical abnormalities and/or alterations that would compromise device delivery or function in the uterus as demonstrated by ultrasound and trial insertion
* 19 ≤ BMI ≤ 29 kg/m2
Exclusion Criteria:
* History of previous moderate or severe ovarian hyperstimulation syndrome (OHSS)
* Severe endometriosis
* Any active infection that would contraindicate ART, at the discretion of the investigator
* Severe male factor in the partner (cryptozoospermia or non-obstructive azoospermia)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Euploidy status after a biopsy on all viable day 5 embryos