Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreo… (NCT02647515) | Clinical Trial Compass
CompletedPhase 4
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
18 participantsStarted 2013-01
Plain-language summary
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing recurrent vitreous hemorrhage (VH) and optimizing postoperative intraocular pressure(IOP)control.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* age≥18 years
* PDVH obscuring the disc and vessels for more than 14 days and no evidence of retinal detachment after primary vitrectomy for PDR-related complications such as nonclearing VH, macula-involving or macula-threatening tractional retinal detachment, or fibrovascular proliferation with vitreoretinal adhesions
* NVG occurred following PDVH less than 4 weeks (NVG was diagnosed when an IOP elevation of 22mmHg or more was accompanied by neovascularization of the iris and/or the anterior chamber angle)
Exclusion Criteria:
* intraoperative use of long-acting gas or silicone oil in primary vitrectomy, repeat vitrectomy after primary vitrectomy for retinal diseases other than VH, previous history of vitrectomy
* previous intravitreal injection of ranibizumab or bevacizumab in either eye
* previous intravitreal corticosteroids injection in either eye
* pregnancy or current oral contraceptive intake
* usage of clopidogrel bisulfate or coumadin
* uncontrolled hypertension and cardiac disease
* uncontrolled renal or liver disease