Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect

Inclusion Criteria: * Age≥3 months * Patients with isolated perimembranous ventricular septal defect with hemodynamic abnormalities. Diameter of the defect is greater than 3mm, and less than 10mm Exclusion Criteria: * Para adverse ventricular septal defect * Muscular ventricular septal defect, subpulmonic ventricular septal defect and septal leaflet posterior atrioventricular canal ventricular septal defect * Patients with severe pulmonary hypertension in right-to-left shunt * Patients with obvious aortic valve prolapse, with moderate or severe aortic regurgitation * Infective endocarditis, and heart cavity neoplasm * Patients with other cardiovascular malformations, which require surgery with cardiopulmonary bypass to correct at the same period