UnknownPhase 4

Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic Shock

Sweden30 participantsStarted 2015-12

Plain-language summary

The aim of this study is to investigate the effects milrinon and levosimandan on n heart function in septic cardiomyopathy and how norepinephrine affects the left and right ventricular function in patients with septick shock using pulmonary artery catheter, conventional and strain echocardiography.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Septic shock. * All patients will be resuscitated with fluids before the inclusion. * Need of Norepinephrine infusion. * Myocardial dysfunction in echocardiogram, either LVEF \< 50% or Global Left Ventricular Systolic strain over -15%. Exclusion Criteria: * History of previous heart disease or pulmonary hypertension. * Age \< 18 years. * Cardiac arrhythmia.

What they're measuring

Changes in LV systolic strain

Timeframe: 1.5 hours

Changes in RV systolic strain

Timeframe: 1.5 hours

Trial details

NCT IDNCT02640846

SponsorSahlgrenska University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-01

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