Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease (NCT02630966) | Clinical Trial Compass
CompletedPhase 4
Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease
United States, Canada34 participantsStarted 2016-08-10
Plain-language summary
The purpose of this study is to evaluate the percentage of participants with perianal fistula healing at Week 30 in 2 different dose regimens of vedolizumab intravenous (IV) 300 milligram (mg) in participants with fistulizing Crohn's disease (CD).
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion criteria
✓. In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
✓. The participant or, when applicable, the participant's legally acceptable representative has signed and dated a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
✓. Has a diagnosis of CD established at least 3 months prior to randomization by clinical and endoscopic evidence and corroborated by a histopathology report.
✓. Has a diagnosis of a minimum of 1 perianal draining fistula of at least 2 weeks duration as a complication of moderately to severely active CD, as identified on magnetic resonance image (MRI) at Screening. Other types of fistulae (enterocutaneous, abdominal) except rectovaginal fistulae are permitted, but the number of perianal draining fistulae is limited to 3.
✓. All countries except France: The participant, historically, had an inadequate response with, lost response to, or was intolerant to either conventional therapy or a tumor necrosis factor-alpha (TNF-α) antagonist for their underlying CD (does not require treatment failure for currently active draining fistula).
✓. If the participant had noncutting perianal seton placement as part of standard care, seton must be removed by Week 14 of the study.
Exclusion criteria
✕. Has a diagnosis of ulcerative colitis or indeterminate colitis.
✕. Has a perianal abscess greater than (\>) 2 centimeter (cm) or an abscess that the investigator feels requires drainage based on either clinical assessment or MRI.
What they're measuring
1
Percentage of Participants With at Least 50% Reduction From Baseline in the Number of Draining Perianal Fistulae (of Those Draining at Baseline)
. Has a Crohn's Disease Activity Index (CDAI) score \>400.
✕. Has an ileostomy, colostomy, or known fixed symptomatic stenosis of the intestine.
✕. Has significant anal or rectal stenosis.
✕. Has active or latent tuberculosis (TB), regardless of treatment history.
✕. Has evidence of active Clostridium difficile (C. difficile) infection or is having treatment for C. difficile infection or other intestinal pathogens during Screening.