Stopped: Other - Protocol moved to Withdrawn
This phase I trial studies the side effects and best dose of talazoparib and heat shock protein (HSP)90 inhibitor AT13387 when given together in treating patients with solid tumors that have spread to other places in the body (metastatic) or ovarian, fallopian tube, primary peritoneal, or hormone negative breast cancer that have come back after a period of improvement (recurrent). Talazoparib and HSp90 inhibitor AT13387 may stop the growth of tumor cells by blocking some enzymes that are need for cell growth. HSp90 inhibitor AT1338 may also help talazoparib work better by making tumor cells more sensitive to the drug.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
MTD based on the dose-limiting toxicity based on the National Cancer Institute (NCI) CTCAE v. 4.0
Timeframe: 35 days