Eosinophilic Esophagitis Intervention Trial-1 Food vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids

Inclusion Criteria: * Have diagnosis of EoE (based on consensus criteria) * Are aged 6 to 17 years * Have histologically confirmed active disease \>15 eosinophils/hpf in either distal or proximal esophagus within 12 weeks of screening visit * Proton Pump Inhibitor (PPI) confirmation * Symptomatic (have experienced symptoms within the last month prior to enrollment) * Has a negative urine pregnancy test at screening if of childbearing potential. Females of childbearing potential must have a negative urine pregnancy test (β-hCG) prior to enrollment into the study (i.e., at screening). Subsequently, these participants must agree to use adequate birth control measures (e.g., condom, oral/injectable/subcutaneous contraceptives, intrauterine device, or sexual abstinence) during the study and for at least one month after the last dose of study drug which will be documented in the source documents. Exclusion Criteria: * Have been treated with topical swallowed steroids within the last 2 months or systemic steroids within the past 3 months * Have eosinophilia in segments of the GI tract other than the esophagus * Have been diagnosed with a GI malabsorption disorder (i.e., Inflammatory bowel disease, Crohn's disease) or Celiac disease * Are currently on dietary therapy avoiding milk * Have concurrent H pylori gastritis or parasitic infection * Are unable to obtain esophagogastroduodenoscopy with esophageal biopsies at Cincinnati Children's Hospital Medical Center (CCHMC) or other pa…