The purpose of study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of Amivantamab as a monotherapy and in combination with lazertinib, and to determine the recommended Phase 2 dose (RP2D) (monotherapy), recommended Phase 2 combination dose (RP2CD) (combination therapy), and to determine recommended Phase 2 Dose (RP2q3W) with combination chemotherapy (Amivantamab in combination with standard of care carboplatin and pemetrexed) in 21 day treatment cycle for participants with advanced non-small cell lung cancer (NSCLC).
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Part 1: Number of Participants With Dose Limiting Toxicity (DLT)
Timeframe: Up to Day 28
Part 2: Number of Participants With Adverse Events (AEs) and Serious AEs
Timeframe: Screening up to follow-up (30 [+7] days after the last dose)
Part 2: Overall Response Rate (ORR)
Timeframe: Up to End of Treatment Follow (EOT) Up Period (30 [+7] days after the last dose)
Part 2: Duration of Response (DOR)
Timeframe: Up to EOT Follow Up Period (30 [+7] days after the last dose)
Part 2: Percentage of Participants With Clinical Benefit
Timeframe: Up to EOT Follow Up Period (30 [+7] days after the last dose)
Trough Serum Concentration (Ctrough) of Amivantamab
Timeframe: Up to EOT (30 days after last dose)
Area Under the Curve From Time Zero to End of Dosing Interval (AUCtau) of Amivantamab
Timeframe: Up to EOT (30 days after last dose)