The purpose of this study is to assess the safety, tolerability and immunogenicity of different vaccination schedules of Ad26.ZEBOV and MVA-BN-Filo administered intramuscularly (IM) as 2-dose heterologous regimens in healthy and in HIV-infected adults.
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Part 1, Part 2 (Group 2): Number of Participants With Unsolicited Adverse Events
Timeframe: Up to 28 days post each dose (up to Day 43)
Part 2 (Group 1): Number of Participants With Unsolicited Adverse Events
Timeframe: Up to 28 days post dose 2 visit (up to Day 57)
Part 1, Part 2 (Group 2): Number of Participants With Serious Adverse Events (SAEs)
Timeframe: Up to 1 year post dose 2 (up to Day 380)
Part 2 (Group 1): Number of Participants With SAEs
Timeframe: Up to 1 year post dose 2 (up to Day 394)
Part 1, Part 2 (Group 2): Number of Participants With Immediate Reportable Events (IREs)
Timeframe: Up to 1 year post dose 2 (up to Day 380)
Part 2 (Group 1): Number of Participants With IREs
Timeframe: Up to 1 year post dose 2 (up to Day 394)
Parts 1 and 2: Number of Participants With Solicited Local Adverse Events (AEs) 7 Days Post First Vaccination
Timeframe: 7 days post dose 1 (up to Day 8)
Part 1, Part 2 (Group 2): Number of Participants With Solicited Local AEs 7 Days Post Second Vaccination
Timeframe: 7 days post dose 2 (up to Day 22)
Part 2 (Group 1): Number of Participants With Solicited Local AEs 7 Days Post Second Vaccination
Timeframe: 7 days post dose 2 (up to Day 36)
Parts 1 and 2: Number of Participants With Solicited Systemic Adverse Events 7 Days Post First Vaccination
Timeframe: 7 days post dose 1 (up to Day 8)
Part 1, Part 2 (Group 2): Number of Participants With Solicited Systemic AEs 7 Days Post Second Vaccination
Timeframe: 7 days post dose 2 (up to Day 22)
Part 2 (Group 1): Number of Participants With Solicited Systemic AEs 7 Days Post Second Vaccination
Timeframe: 7 days post dose 2 (up to Day 36)
Part 1, Part 2 (Group 2): Geometric Mean Concentrations (GMCs) of Binding Antibody Levels Against Ebola Virus Glycoprotein (EBOV GP) Measured Using Filovirus Animal Non-Clinical Group (FANG) Enzyme-linked Immunosorbent Assay (ELISA)
Timeframe: 21-days post dose 2 (up to Day 36)
Part 2 (Group 1): GMCs of Binding Antibody Levels Against EBOV GP Measured Using FANG ELISA
Timeframe: 21-days post dose 2 (Day 50)