Pharmacokinetics of Ciprofloxacin in Pediatric Patients (NCT02598362) | Clinical Trial Compass
CompletedPhase 4
Pharmacokinetics of Ciprofloxacin in Pediatric Patients
Belgium22 participantsStarted 2015-04
Plain-language summary
Measuring serum and urine concentrations of ciprofloxacin after IV and oral administration in children aged 3 months - 17 years who are treated for urinary tract infections.
Who can participate
Age range3 Months – 17 Years
SexALL
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Inclusion Criteria:
* age between 3 months and 17 years of age
* confirmed diagnosis of febrile urinary tract infection (a rectal body temperature of 38.5 °C.in combination with either significant leukocyturia or a positive urine nitrite test in a reliable urine sample.
* indication for treatment or uroprophylaxis with ciprofloxacin at discretion of the treating physician.
Exclusion Criteria:
* pregnancy
* impaired renal function as defined by 2x serum creatinine level for age and sex
* epilepsy
* myasthenia gravis
* long QT-syndrome
* glucose 6 phosphatase deficiency (G6PD)
* allergy to one of the substances of cipro
* concomitant use of corticosteroids
* for the oral group: co medication of antacidic drugs, ferrofumarate, calcium, magnesium or Zinc supplements.