CompletedPhase 2/3

Intravenous Lidocaine for Post-Tonsillectomy Pain in Pediatric Patients

United States89 participantsStarted 2015-11

Plain-language summary

The purpose of this study is to determine whether giving lidocaine intravenously during and after a tonsillectomy surgery is effective in decreasing postoperative pain.

Who can participate

Age range

4 Years – 10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Scheduled for Tonsillectomy (with or without Adenoidectomy) with Dr. Kathleen Billings or Dr. Stephen Hoff at Lurie Children's Hospital * American Society of Anesthesiology (ASA) patient classification I-III (Healthy patient to a patient with mild systemic disease) Exclusion Criteria: * Physical or developmental delays * Psychiatric illness * Current use of sedative or anticonvulsant medications * Pre-existing renal disease (ranging from stage 2 \[mild\] to stage 5 \[end stage\]) * Pre-existing cardiovascular disease (including, not limited to congenital heart disease or arrythmia) * Pre-existing liver disease * Pre-existing cerebral or neuromuscular disease * Patient or family history of Malignant Hyperthermia * Recent history of upper respiratory infection within last 7 days * Regular use of analgesic medication * Diagnosis of severe obstructive sleep apnea requiring overnight stay for observation * Other procedure scheduled in addition to tonsillectomy * History of allergies to local anesthetics

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Observer Rated Pain Intensity

Timeframe: Within the immediate post-operative period (90 minutes after surgery)

Trial details

NCT IDNCT02595463

SponsorAnn & Robert H Lurie Children's Hospital of Chicago

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-05

View on ClinicalTrials.gov More Pain trials

Who can participate

Age range

4 Years – 10 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.