Switching Regimen in Treating Cirrhotic HCV GT1b Subjects

Inclusion Criteria: * Individuals with chronic HCV GT1b infection; * HCV RNA ≥ 10000 IU/mL at screening; * Received 4 weeks pegylated interferon plus ribavirin (PR4) therapy and are intolerant to PR4; * Cirrhosis determination; a liver biopsy may be required; * Use of highly effective contraception methods if female of childbearing potential or sexually active male; Exclusion Criteria: * Pregnant or nursing female or male with pregnant female partner; * HIV or HBV co-infection; * Hematologic or biochemical parameters at Screening outside the protocol- specified requirements; * Active or recent history (≤ 1 year) of drug or alcohol abuse; * History or current evidence of any condition, therapy, laboratory abnormality or other circumstance that might confound the results of the study, or interfere with the subject's participation for the full duration of the study, such that it is not in the best interest of the subject to participate.