Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain (NCT02578108) | Clinical Trial Compass
CompletedNot Applicable
Diagnostic Genicular Nerve Block Prior to Radiofrequency Ablation for Knee Osteoarthritis Pain
United States63 participantsStarted 2015-10
Plain-language summary
Chronic painful knee OA is a major cause of disability in older adults. In patients whose symptoms are refractory to conservative management but who do not wish to undergo TKA or, alternatively, are not operative candidates, genicular nerve RFA represents a promising treatment option.
Investigators will determine if patients with chronic painful knee osteoarthritis experience meaningful and long-term improvement in pain, function, and analgesic use, as well as prevention of TKA after RFA of the genicular nerves. Investigators will also determine whether zero versus one set of diagnostic genicular nerve blocks
Answering these questions will help determine if genicular nerve RFA is indeed a worthwhile treatment for chronic painful knee OA. Additionally, this will help determine the optimal diagnostic protocol for patient selection for this procedure, which has implications for improving treatment success rates, preventing unnecessary procedures, and decreasing healthcare cost savings.
Who can participate
Age range30 Years – 80 Years
SexALL
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Inclusion criteria
✓. All patients ages 30-80 with chronic painful knee osteoarthritis who would undergo treatment by genicular nerve radiofrequency ablation.
✓. Knee pain for at least 6 months.
✓. Kellgren-Lawrence knee osteoarthritis of 2 or greater.
✓. Pain resistant to conventional therapy including NSAIDs, opioids, muscle relaxants, oral steroids, physical therapy, and intra-articular injection therapy.
✓. No pain referral beyond the expected distribution for knee osteoarthritis.
Exclusion criteria
✕. NRS pain score of 4 or more
✕. Focal neurologic signs or symptoms.
✕. Previous radiofrequency ablation treatment for similar symptoms.
✕. Intra-articular knee corticosteroid or hyaluronic acid injection in the past 3 months.
✕
What they're measuring
1
>50% relief of pain from before to after radiofrequency ablation of the genicular nerves