Cognitive Remediation to Improve Mobility in Sedentary Seniors (NCT02567227) | Clinical Trial Compass
CompletedNot Applicable
Cognitive Remediation to Improve Mobility in Sedentary Seniors
United States383 participantsStarted 2016-03
Plain-language summary
The investigators propose to conduct a single-blind randomized clinical trial to test the efficacy of a computerized cognitive remediation intervention program on improving locomotion in sedentary seniors, a group at an especially high risk for disability. The hypothesis is that executive functions will respond to the cognitive remediation program and in turn enhance locomotion.
Who can participate
Age range70 Years
SexALL
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Inclusion criteria
✓. Adults aged 70 and older, residing in the community.
✓. Plan to be in area for next year.
✓. Able to speak English at a level sufficient to undergo our cognitive assessment battery.
✓. Ambulatory. Subjects are classified as 'non-ambulatory' if they are unable to leave the confines of their home and attend a clinic visit.
✓. Gait velocity ≤1 m/s.
✓. Short Physical Performance Battery score ≤9.
Exclusion criteria
✕. Presence of dementia identified by any one of the following: Telephone based Memory Impairment Screen score (T-MIS) of \<5, Alzheimer's Disease 8 (AD8) ≥ 2. Or dementia diagnosed by baseline cognitive assessment.
✕. Serious chronic or acute illness such as cancer (late stage, metastatic, or on active treatment), chronic pulmonary disease on ventilator or continuous oxygen therapy or active liver disease.
✕. Mobility limitations solely due to musculoskeletal limitation or pain (e.g., severe osteoarthritis) that prevent subjects from completing mobility tests. Presence of arthritis will not be used to exclude subjects if they can complete the mobility tasks.
✕. Any medical condition or chronic medication use (e.g., neuroleptics) that will compromise safety or affect cognitive functioning or terminal illness with life expectancy less than 12 months.
✕
What they're measuring
1
Change in Walking Speed During Single and Dual-task Conditions.
. Presence of progressive, degenerative neurologic disease (e.g., Parkinson's disease or ALS).
✕. Hospitalized in the past 6 months for severe illness or surgery that specifically affects mobility (e.g. hip or knee replacement) and that prevent subjects from completing mobility tests or plans for surgery affecting mobility in the next 6 months.
✕. Severe auditory or visual loss.
✕. Active psychoses or psychiatric symptoms (such as agitation) noted during the clinic visit that will prevent completion of study protocols.