Preoperative vs Postoperative IMRT for Extremity/Truncal STS (NCT02565498) | Clinical Trial Compass
Active — Not RecruitingPhase 3
Preoperative vs Postoperative IMRT for Extremity/Truncal STS
United States, Belgium, Canada210 participantsStarted 2016-06
Plain-language summary
This study is designed to determine if preoperative image guided radiation therapy (IGRT) delivered using intensity modulated radiation therapy (IMRT) followed by surgery results in similar short-term wound healing complications as surgery followed by postoperative IGRT in patients with extremity or truncal soft tissue sarcoma. Half of the patients will receive preoperative radiotherapy, half will receive postoperative radiotherapy.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Histologically proven soft tissue sarcoma of the extremity or trunk following review by local reference pathologist.
✓. Deemed appropriate for preoperative or postoperative radiotherapy and conservative surgery following patient assessment by a radiation oncologist and surgical oncologist.
✓. Lesion is primary or locally recurrent. Patient may have undergone excisional biopsy with positive margins at a referring hospital and are eligible following discussion among the surgical oncologists and radiation oncologists that IMRT is an acceptable treatment for that case.
✓. Eastern Cooperative Oncology Group (ECOG) score 0-3
✓. Patient is aged 18years or older.
✓. Patient is able to provide informed consent
✓. Patient is available for treatment and follow-up.
Exclusion criteria
✕. Benign histology.
✕. Prior malignancy within the previous five years or concurrent malignancy with the exception of adequately treated basal cell carcinoma of the skin or carcinoma in-situ of the cervix.
✕. Prior radiotherapy to the target site
✕. Planned chemotherapy for (neo)adjuvant treatment