MRI-Based Active Surveillance to Avoid the Risks of Serial Biopsies in Men With Low-Risk Prostate Ca

Inclusion Criteria: * Prostate adenocarcinoma diagnosed by biopsy within 12 months prior to study registration. * Gleason score ≤ 6 * PSA \< 10 ng/mL * Completed and documented history and physical addressing all inclusion/exclusion criteria. Exclusion Criteria: * A diagnosis of prostate adenocarcinoma on more than one set of prostate biopsies, on separate calendar dates. * Previous MRI imaging of the prostate. * Prior history of pelvic radiotherapy. * Prior history of prostatectomy. * Contraindication to prostate mpMRI (renal failure, hip prosthesis, pacemaker, etc). * Contraindication to prostate biopsy via transrectal or transperineal approaches (including coagulopathy). * Patients on testosterone replacement therapy who are unwilling to discontinue. * Medical, psychological, or social condition that, in the opinion of the investigator, may increase the patient's risk or limit the patient's adherence with study requirements. * Unable to understand, or unwilling to complete the informed consent process.