The main purpose of this study is to evaluate the safety of the study drug known as ramucirumab in children with recurrent or refractory solid tumors including central nervous system (CNS) tumors.
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Part A: Number of Participants With Dose Limiting Toxicities (DLTs): Maximum Tolerated Dose of Ramucirumab
Timeframe: Baseline to Study Completion (Up to 42 Months)
Population Pharmacokinetics (PK): Minimum Concentration (Cmin) of Ramucirumab
Timeframe: Predose, Cycle 1 Day 1 (end of infusion (EOI), 1 hour after EOI) and Cycle 1 Day 43 (1 hour after EOI)
Number of Participants With Anti-Ramucirumab Antibodies
Timeframe: Predose Cycle 1 Day 1 through Follow-Up (Up to 42 Months)