A prospective open label, multicenter study to evaluate the feasibility and acute toxicity of using molecularly guided therapy in combination with standard therapy followed by a Randomized Controlled Trial of standard immunotherapy with or without DFMO followed by DFMO maintenance for Subjects with Newly Diagnosed High-Risk Neuroblastoma.
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Number of days from start of therapy to date of first relapse
Timeframe: Up to 8 years
Number of subjects that have a targeted agent chosen for treatment.
Timeframe: 2 years
Number of subjects that receive 75% of dosing of medications while on study protocol during cycles 3-6.
Timeframe: 2 years