Patients with active Axial Spondyloarthritis without x-ray evidence of Ankylosing Spondylitis and with signs of inflammation will be randomly assigned to receive certolizumab pegol (CZP) 200 mg every two weeks or placebo. The primary objective is to demonstrate the efficacy of CZP in these patients.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Percentage of Subjects With Ankylosing Spondylitis Disease Activity Score Major Improvement (ASDAS-MI) Response Criteria Response at Week 52
Timeframe: Week 52
Percentage of Subjects With Axial SpondyloArthritis International Society 40% Response Criteria (ASAS40) Response at Week 12
Timeframe: Week 12
Certolizumab Pegol Plasma Concentration at Baseline
Timeframe: Baseline (Week 0)
Certolizumab Pegol Plasma Concentration at Week 1
Timeframe: Week 1
Certolizumab Pegol Plasma Concentration at Week 2
Timeframe: Week 2
Certolizumab Pegol Plasma Concentration at Week 4
Timeframe: Week 4
Certolizumab Pegol Plasma Concentration at Week 12
Timeframe: Week 12
Certolizumab Pegol Plasma Concentration at Week 24
Timeframe: Week 24
Certolizumab Pegol Plasma Concentration at Week 36
Timeframe: Week 36
Certolizumab Pegol Plasma Concentration at Week 52
Timeframe: Week 52
Certolizumab Pegol Plasma Concentration at Follow-Up (FU) Visit
Timeframe: Follow-up Visit (up to Week 60)