Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction (NCT02544087) | Clinical Trial Compass
UnknownNot Applicable
Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction
China120 participantsStarted 2015-04
Plain-language summary
The present study is designed to confirm the therapeutic effects of heat-clearing and blood-activating Chinese medicinal components in treatment of Acute Cerebral Infarction (ACI) and to investigate the therapeutic mechanisms of multi-target anti-inflammatory action involved from the standpoint of pathology, cell and molecular biology, as well as immunology.
Who can participate
Age range40 Years – 80 Years
SexALL
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Inclusion Criteria:
* Patients with acute ischemic stroke
* Patients with fire-heat syndrome
* Stroke onset within 48 hours
* NIHSS scores range from 5 points to 25 points
* Age from forty to eighty,gender not limited
* Informed and signed the consent
Exclusion Criteria:
* Cardiogenic cerebral embolism,stroke caused by other reasons or the unexplained
* Patients suitable for thrombolytic therapy(rt-PA,urokinase),or have recieved thrombolytic therapy
* Patients suitable for endovascular therapy,or have recieved endovascular therapy
* Patients with serious disease of heart,lungs,liver or kidneys(The value of ALT or AST is more than 2 times of the upper limit of normal range,the value of creatinine is more than 1.5 times of the upper limit of normal range,asthma or COPD,or cardiac function level 4)
* Patients with bleeding or bleeding tendency recently
* Pregnant or lactating women
* Pre-existing limb dysfunction, psychiatric diaseses,or cognitive dysfunction that could confound the study results
* Patients with allergic constitutions,or have the contraindication of Ixeris of sonchifolia Hance components(KDZ injection) or Panax notoginseng saponins components(Xueshuantong injection)
* Patients have participated in other clinical trials within 3 months