Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in The… (NCT02537067) | Clinical Trial Compass
TerminatedPhase 3
Efficacy and Safety of Chondron (Autologus Chondrocyte) in Patients With Cartilage Defects in Their Ankle
Stopped: The study was terminated early due to company reasons.
South Korea28 participantsStarted 2010-01
Plain-language summary
The objective of this study is to evaluate the efficacy and safety of Chondron (Autologus Chondrocyte) in patients with cartilage defects in their ankle for 18 months
Who can participate
Age range
15 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female subjects aged 15 to 65 years
* Patients with MRI-confirmed partial cartilage defects of the ankle (≤15 cm² single lesion, ≤20 cm² multiple lesions)
* Patients who have undergone correction for malalignment, ligament instability, or bone defects (if applicable)
* Patients with normal surrounding cartilage
* Patients with ICRS Grade III or IV cartilage defects
* Subjects who provide written informed consent
Exclusion Criteria:
* Hypersensitivity to bovine protein or gentamicin
* Inflammatory or autoimmune arthritis (e.g., rheumatoid arthritis, gout)
* Pregnant, breastfeeding, or planning pregnancy
* Tumors or serious comorbid conditions
* History of radiotherapy or chemotherapy within 2 years
* Uncontrolled diabetes or diabetes with complications
* Active infection requiring antibiotics
* Current corticosteroid therapy
* Patients with mental illness or other conditions deemed unsuitable for this study by the clinical trial manager
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Grade change of ICRS(International Cartilage Repair Society) by arthroscopy