Nivolumab in AML in Remission at High Risk for Relapse

Inclusion Criteria: * Patients with AML in remission (defined as CR, CR with incomplete platelet recovery -CRp-, CR with incomplete hematologic recovery -CRi-, or partial remission defined as a bone marrow with \< 10% blasts after therapy with or without hematologic recovery) * High risk for relapse defined as: 1st CR with high risk features for relapse (including history of prior malignancy treated with chemotherapy or radiotherapy, or history of myelodysplastic syndrome, myeloproliferative disorder, chronic myelomonocytic leukemia, myelodysplastic syndrome \[MDS\]/myeloproliferative neoplasm \[MPN\] or other hematologic malignancy thought to have evolved to AML \[i.e., secondary AML, (sAML)\]; high risk cytogenetics at diagnosis; fms-related tyrosine kinase 3 \[FLT3\] mutated at diagnosis; or presence or minimal residual disease assessed by polymerase chain reaction \[PCR\], cytogenetics, and/or flow cytometry at time of enrollment) 2nd CR regardless of disease characteristics at the time of diagnosis * Have received induction chemotherapy and at least one cycle of consolidation chemotherapy; patients should have achieved a CR within 12 months of enrollment onto protocol * No further chemotherapy or stem cell transplant (SCT) planned at the time of enrollment * Creatinine =\< 1.5 x upper limit of normal (ULN) * Serum bilirubin =\< 1.5 x ULN * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x ULN * Eastern Cooperative Oncology Group (ECOG) perfor…