CompletedNot Applicable

Non Invasive Ventilation Combined to High Flow Nasal Cannula Oxygen for Preoxygenation of Hypoxemic ICU Patients

France50 participantsStarted 2015-06-23

Plain-language summary

Tracheal intubation is a challenging procedure in Intensive Care Unit (ICU), associated with severe life threatening complications. To decrease these complications, preoxygenation is recommended. Non invasive ventilation (NIV) increase effectiveness of preoxygenation, applying a positive end expiratory pressure (PEEP). High-flow nasal cannula oxygen (HFNC) improves oxygenation by increasing end-expiratory lung volume and has a potential of apneic oxygenation. The association of NIV and HFNC for preoxygenation in hypoxemic ICU patients has never been evaluated. The aim of this study is to determine if HFNC combined to NIV could have therapeutic advantages over NIV alone for preoxygenation in the ICU patients intubated for hypoxemic acute respiratory failure.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult hypoxemic patients * Patients intubated in the ICU for acute respiratory failure (Hypoxemia is defined by the need of a FiO2\>50% to maintain a SpO2\>90% and a PaO2/FiO2 ratio\<300 mmHg under mask oxygen therapy with a flow of 15L/min (measured during the 4 hours before inclusion)). Exclusion Criteria: * non adult patients (age \<18 years) * pregnant woman * protected persons * Patient intubated in case of cardio circulatory arrest * Patient with nasopharyngeal obstacle contraindicating the use of HNFC

What they're measuring

Lowest oxygen saturation

Timeframe: 1 years

Trial details

NCT IDNCT02530957

SponsorUniversity Hospital, Montpellier

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-02-28

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