Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Resten… (NCT02529189) | Clinical Trial Compass
CompletedPhase 2
Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina
United Kingdom300 participantsStarted 2015-11-02
Plain-language summary
The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. Whilst this procedure has revolutionised treatment the incidence of secondary events remains a concern. These repeat events are due in part to continued enhanced platelet reactivity, endothelial dysfunction and a phenomenon called 'restenosis' i.e. the stent becomes blocked ultimately requiring another expensive and risky procedure. In this study it will be determined whether a once daily inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis.
Who can participate
Age range18 Years – 85 Years
SexALL
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Inclusion criteria
✓. Patients with stable angina diagnosed by a cardiologist on optimal medical therapy undergoing angioplasty to treat residual symptoms.
✓. Aged 18-85
✓. Patients able and willing to give their written informed consent.
. Use of an investigational device or investigational drug within 30 days or 5 half-lives (whichever is the longer) preceding the first dose of study medication.
✕. Patients considered unsuitable to participate by the research team (e.g., due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures).
✕. Severe acute infection, or significant trauma (burns, fractures).