Comparison of CLE in Vivo Diagnosis and ex Vivo Examination Against Surgical Histopathology of CPL

Inclusion Criteria: For in vivo nCLE (needle-based confocal laser endomicroscopy) (Part 1): * Patient age 18 years and older * All patients referred for EUS-FNA (endoscopic ultrasound - fine needle aspiration) of accessible CPL (cystic pancreatic lesion) * The minimum size of the cyst should be ≥ 1.5 cm as determined by prior cross-sectional imaging studies. For ex vivo pCLE (probe-based confocal laser endomicroscopy) (Part 2): * All patients must satisfy inclusive criteria for in vivo nCLE. * All patients should have completed EUS-guided nCLE. * All patients should have a CPL lesion referred for surgical removal based on recommended international consensus guidelines1 and inter-departmental consensus pancreatic tumor board meeting (departments of surgical oncology, radiology, pathology and gastroenterology). * Patient participated and completed in vivo nCLE (Part 1) Exclusion Criteria: * Unable to obtain informed consent * Unable to tolerate the procedure * Women with known pregnancy at time of procedure * Patient age less than 18 years * Bleeding diathesis * Lesion not accessible by EUS guided FNA * Allergy to fluorescein.