Gulf War Illness Inflammation Reduction Trial

Inclusion Criteria: * Scores moderate-severe on at least 3 out of 6 domains from the Kansas GWI Case Definition * Deployed, (and honorably discharged), from the Kuwaiti Theater of Operation (August 2, 1990-July 31, 1991) Exclusion Criteria: * Hospitalization anytime since 1990 for Alcohol or Drug Dependence, Depression, or PTSD * Known hypersensitivity to Prednisone * Liver, (active or recent Hepatitis B or C treatment with a completion date within the past 6 months, or alcohol liver disease), or Kidney Disease (Hep B and C ok if after 6 months of treatment) * Treated Diabetes * Females who are Pregnant or Nursing * Female who refuses to use an accepted method of birth control * Exclusionary Labs: C-Reactive Protein \>25, Creatinine Clearance \<30, EFGR ≥ 30, Hgb A1-C \>7, Glucose \>120, WBC \>12, RBC \>6.2, Hematocrit \>60, Hemoglobin \<11, Platelets \<100, Liver Function Tests (2 x the upper limit of AST and ALT, 2 x the upper limit of Total Bilirubin, and Alkaline Phosphatase) * Has Inflammatory Arthritis (RA, or Psoriatic Arthritis, Spondylitis, Polyarthritis) * Reactive Arthritis, or IBD associated Arthritis * Has any major inflammatory disease (acute Chronic Infections, Ulcerative Colitis, Crohn's Disease, Inflammatory lung diseases- COPD or Asthma requiring steroid treatment, Pericarditis, Vasculitis) * Has an chronic/active infection * Chronic use of Prednisone or Corticosteroids (occasional inhaled use of steroids acceptable) * Active Gum Disease or Dental Infecti…