Obesity and Lipids: a Matter of Taste? (NCT02497274) | Clinical Trial Compass
CompletedNot Applicable
Obesity and Lipids: a Matter of Taste?
20 participantsStarted 2016-01-11
Plain-language summary
The purpose of the protocol is to determine the impact of bariatric surgery on taste receptors and taste perceptions and to precise the factors implicated in taste alterations in 50 obese patients before and 6 months after bariatric surgery (25 Roux Y gastric bypass and 25 sleeve gastrectomy).
Who can participate
Age range18 Years – 55 Years
SexFEMALE
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Inclusion Criteria:
* Affiliation to a health insurance
* Patients candidates for bariatric surgery based on criteria established by international experts (BMI\> 40 or\> 35 kg / m² with severe comorbidities, after failure of multidisciplinary care for a period of at least 1 year)
* Written consent after oral and written informations
Exclusion Criteria:
* Topic guardianship, curatorship or safeguard justice.
* Taking a treatment known to alter the perception of taste
* Oral Decay can affect the perception of taste
* Treatment that may interfere with intestinal peptides or lipids receptors (especially DDP4 inhibitors, anti-inflammatory medications, intestinal lipase inhibitors: Xenical)
* Tobacco use, alcohol or drugs abuse
* Known coagulopathy, abnormal hemostasis tests or abnormal platelets count, treatment interfering with coagulation or platelet aggregation
* Contraindication to bariatric surgery
* Malignant pathology, severe liver disease or severe inflammatory disease, malabsorption.
* Pregnancy
* Positive serology for VIH, VBH and CVH
What they're measuring
1
Expression of lipid receptors
Timeframe: before and 6 months after bariatric surgery