WithdrawnNot Applicable

Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation

Stopped: Lack of funding

United States0Started 2015-11

Plain-language summary

The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation. The investigators hypothesized that a titrated level of PEEP ("Titrated-PEEP") during SBT will keep the lung recruited, maintain oxygenation, and decrease the work of breathing resulting in successful ventilator liberation. In addition, post-extubation the investigators hypothesize that these patients will require noninvasive ventilatory support in the form of CPAP at the level of "titrated-PEEP" used during the SBT.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Intubated and mechanically ventilated; * Weaning from mechanical ventilation; * BMI ≥ 35 kg/m2 with waist circumference \> 88 cm for women; waist circumference \> 102 cm for men. * A well functioning arterial line. Exclusion Criteria: * Known presence of esophageal varices * Recent esophageal trauma or surgery * Severe thrombocytopenia (PTL ≤ 5,000/mm3) * Severe coagulopathy (INR ≥ 4) * Presence of pneumothorax * Pregnancy * Pacemaker and/or internal cardiac defibrillator

What they're measuring

Differences in WOB at titrated PEEP levels vs. ZEEP level

Timeframe: 24 hours

Trial details

NCT IDNCT02492113

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-24

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