A Dose-response Evaluation of the SQ Tree SLIT-tablet Using an Environmental Exposure Chamber

Inclusion Criteria: * Written informed consent obtained before any trial related procedures are performed * Male or female aged 18 to 65 years * Female subjects of child-bearing potential must have a negative urine pregnancy test and be willing to practise contraceptive methods * History of moderate-to-severe rhinoconjunctivitis induced by pollens from the birch group with or without asthma despite having received treatment with symptom relieving medication during the previous 2 tree pollen seasons * Positive SPT response (wheal diameter ≥ 3 mm) to Betula verrucosa * Positive specific IgE against Bet v1 (≥ IgE Class 2; ≥0.70 kU/L) * Willing and able to comply with the trial protocol * Minimum level of rhinoconjunctivitis symptoms, defined as a TSS of at least 7 (of 18), at one timepoint during birch baseline EEC session. Exclusion Criteria: * Symptoms induced by interfering allergens that are expected to be present during the periods where the subject attends the EEC sessions * Rhinoconjunctivitis caused by animal hair and dander to which the subject is regularly exposed. * Allergic symptoms induced by perennial allergens such as house dust mites, and moulds * A clinical history of uncontrolled asthma within 3 months prior to screening * Reduced lung function FEV1 (\< 70% of predicted value after adequate pharmacological treatment) * Asthma requiring treatment with inhaled corticosteroid within the past 3 months prior to screening * Previous treatment with any allergy immu…