A Study of Gemcitabine/Nab-paclitaxel and Radiation Therapy Followed by Surgery in Patients With Advanced Pancreatic Cancer

Inclusion Criteria: Surgical: * Medically fit for major pancreatic surgery * No evidence of metastases * No prior resection * Arterial involvement limited to a single major vessel and is resectable * Tumour-free margins could be achieved * Acceptable length of vessel * Mass considered otherwise resectable by current standards General: * Less than 70 years old * Performance status \<=2 * Has pancreatic adenocarcinoma * Adequate bone marrow and organ function * Therapeutic heparin is allowed * Taking chronic erythropoietin are permitted * Not pregnant * Agree to use contraception * Able to provide written consent Exclusion Criteria: Surgical: * Aortic involvement * Involvement of 2 major arterial trunks * SMV/portal venous occlusion, cannot be reconstructed * Extensive venous involvement, no arterial involvement * Disease progression on neo-adjuvant treatme General: * Concurrent cancer diagnosis * Other malignancies unless all therapy completed, no disease for \>=3 years * Prior radiotherapy or chemo within 1 year, to pancreas * Bone marrow transplant/stem cell rescue * Major surgery \<4 wks prior * Distant metastases * Renal dysfunction * Pulmonary insufficiency * History of cardiac disease * Active systemic infection(s) or any other related illnesses * Known HIV, HBV, HCV * History of solid organ transplant, cardiovascular disease, inflammatory bowel disease, or underlying neuropathy * Conditions interfering with patient participation * Known or suspected allergy to …