A Study With SAGE-547 for Super-Refractory Status Epilepticus

Exclusion criteria

• ✕. a glomerular filtration rate (GFR) low enough to warrant dialysis but for whatever reason, dialysis is not planned or non-continuous dialysis planned (that would not adequately remove Captisol®);
• ✕. severe cardiogenic or vasodilatory shock requiring two or more pressors that is not related to third-line agent use;
• ✕. fulminant hepatic failure;
• ✕. no reasonable expectation of recovery (for instance, a likely outcome is persistent vegetative state) or life-expectancy, in the experience of the investigator, is less than 30 days.