Optimal Human Dose for GII.2 Norovirus (Snow Mountain) Challenge Studies

Inclusion criteria

• ✓. Subject able to provide written informed consent
• ✓. Male or non-pregnant females between the ages of 18 and 49 years, inclusive
• ✓. Women of childbearing potential must be practicing abstinence or using an acceptable method of birth control for at least 30 days prior to enrollment through day 45 after receipt of the challenge virus. Male subjects must agree not to father a child prior to day 45 after receipt of the challenge virus
• ✓. For women of childbearing potential, must have a negative serum or urine pregnancy test at screening and negative urine pregnancy test within 24 hours prior to challenge
• ✓. Are in good general health, as determined by the study investigator within 60 days of challenge
• ✓. Demonstrate knowledge and comprehension of the study by scoring \>/= 70 percent on a quiz of the study protocol and policies
• ✓. Willing and able to participate in all study visits, including an inpatient stay of at least 96 hours
• ✓. Demonstrated to be H type I secretor positive for HBGA binding by assay of saliva (this applies to all cohorts except the SN cohort, which will include secretor negative subjects only)

Exclusion criteria