Effect of Vitamin E on Skin Aerobic Bacteria in Palmar Arsenical Keratosis

Inclusion Criteria (Patients): * History of drinking arsenic contaminated water (\>50 µg/L) for more than 6 months * Patients having moderate palmar keratosis * Patients those voluntarily agree to participate Inclusion Criteria (Arsenic exposed controls): * Family members of the patient * History of drinking arsenic contaminated water (\>50 µg/L) * Those voluntarily agree to participate * No sign/symptoms of palmar keratosis Inclusion Criteria (Healthy volunteers): * Drinking arsenic safe water (\<50 µg/L) * Those voluntarily agree to participate Exclusion Criteria: * Pregnant and lactating mother * Any other chronic disease like tuberculosis, diabetes, asthma * Patients under treatment of arsenicosis