Ovarian Reserve After Cancer: Longitudinal Effects

Inclusion Criteria for exposed population: * Postmenarchal females to be treated with chemotherapy * between the ages of 11-35 years, * with a uterus and at least one ovary Inclusion Criteria for unexposed population: * healthy postmenarchal females * no prior or planned exposure to chemotherapy * between the ages of 11-35, * with a uterus and at least one ovary * regular menstrual cycles (21-35 days) Exclusion criteria for all subjects: * positive pregnancy test at enrollment * lactation within the previous 1 month, * previous treatment with chemotherapy or radiation therapy with the exception of radioactive iodine for thyroid cancer. * previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) * endocrine disorder associated with irregular menstrual cycles (Cushing's disease, Thyroid disease, hyper-prolactinemia, congenital adrenal hyperplasia). Additional exclusions for the unexposed population: * a history of infertility, defined as at least 12 months of unprotected intercourse without conception * polycystic ovary syndrome (PCOS)