Alendronate Compared to Metformin in Chronic Periodontitis

Inclusion Criteria: * All the subjects were systemically healthy * subjects with sites having CAL ≥ 3 mm, PPD ≥ 5 mm, * vertical bone loss ≥ 3 mm on intraoral periapical radiographs (IOPA) and * subjects with no history of periodontal intervention in the last 6 months. Exclusion Criteria: * patients with systemic diseases like cardiovascular disease * diabetes or HIV infection or on medications like corticosteroids which may impede the healing in periodontal tissues. * pregnant/lactating females * tobacco users * alcoholics * patients with unsatisfactory oral hygiene (plaque index greater than 1.5) * teeth having gingival recession, caries involving pulp, intrabony defect present interproximally, grade 2/3 mobility * Furthermore, patients allergic to Metformin and alendronate or those taking Metformin and alendronate systemically were excluded.