Nutrition and Energy Restriction for Cancer Prevention

Inclusion Criteria: * Women and men aged 35 to 65 years * Overweight or obese (BMI ≥ 25 kg/m2 ≤ 40 kg/m2 ) * German speaking * Non- smoker * Provision of written informed consent Exclusion Criteria: * Not able to understand and sign the informed consent form in person * Already diagnosed diabetes * HbA1c ≥ 6.5 % and/or fasting plasma glucose \> 125 mg/dl * History of cancer within the past 10 years * Risk of bleeding disorders (e.g. Marcumar intake) * Current or history of eating disorders (bulimia, anorexia, binge-eating) * Pregnant or lactating during the past 12 months * Increased or decreased thyroid-stimulating hormone in baseline blood check * Already diagnosed hepatic dysfunction and/or increased or decreased γ-GT, GPT and/or GOT in baseline blood check * Already diagnosed kidney dysfunction and/or increased or decreased creatinine, urea and/or uric acid in baseline blood check * Medications that might affect the endpoints of the study e.g. immunosuppressive medication (cortisol, antibody treatment), hormone replacement therapy, medication for fat metabolism (e.g. statine, fibrate) * Participation in another intervention study shorter than three months ago