Not Yet RecruitingNot Applicable

Polarization Sensitive Optical Coherence Tomography (PS-OCT) for Retinal Imaging

United States20 participantsStarted 2026-06

Plain-language summary

The aim of this pilot study is to assess the ability of a new polarization sensitive optical coherence tomography system to obtain high-quality images of retinal birefringence.

Who can participate

Age range18 Years – 85 Years

SexALL

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Inclusion criteria

✓. Male or female subjects between the ages of 18-85 years
✓. Healthy normal subjects with no significant eye disease, except for mild cataracts
✓. Subjects with clear enough cornea or clear enough media to permit imaging
✓. Subjects with refractive error between -5.00 sph to +5.00 sph

Exclusion criteria

✕. Subjects who have occludable narrow angles (without a patent peripheral iridotomy) or any other ocular or systemic pathology, which precludes safe dilation
✕. Subjects whose eyes have been dilated for over 6 hours will not be eligible for imaging.
✕. Subjects who do not or cannot understand the instructions for the PS-OCT imaging
✕. Subjects who are pregnant and/or breastfeeding. Date of last menstrual cycle will also be included.

What they're measuring

Average nerve fiber layer (NFL) birefringence

Timeframe: At time of imaging

Trial details

NCT IDNCT02441777

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12

Contact for this trial

Benjamin Vakoc, PhD

617-726-0695 bvakoc@partners.org

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