Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Bone Sites

Inclusion Criteria: * To be eligible for this study, each of the following criteria must be satisfied with a "YES" answer (unless not applicable): Patients who: * have had operative fracture fixation of the upper extremity (AO/OTA class 15, 11-13, 21-23), lower extremity (AO/OTA class 31-34, 41 44, 81, 82) or pelvis (61, 62), or have undergone arthrodesis, and have subsequently been diagnosed with an apparent fracture site infection or are diagnosed with chronic or acute-on-chronic osteomyelitis of the long bone extremities (including residual amputated limbs) * have at least one of the following: * require surgical debridement of infected soft tissue and/or bone, with or without removal and/or placement/replacement of hardware * male or female between the ages of 18 and 75 at the time the ICF is reviewed and signed * patients receiving or anticipated to receive systemic antibiotic therapy as per institution's standard of care * patients requiring postoperative hospitalization for at least 48 hours after revision surgery * have read and signed the Informed Consent Form (ICF) after the nature of the study has been fully explained * be willing and able to provide authorization for use and disclosure of personal health information in accordance with the Health Insurance Portability and Accountability Act (HIPAA) Exclusion Criteria: * To be eligible for this study, each of the following criteria must be satisfied with a "NO" answer (unless not applicable): * Patients who …