Effect of DHEA on Patients With Poor Ovarian Responds

Inclusion Criteria: * Indicated for IVF treatment according to our standard department protocol * Age \< 42 * Regular menstrual cycles (21-35 days) Poor ovarian responders are defined according to the Bologna criteria fulfilling 2 out of 3 of the following: * Advanced maternal age (≥40) or any other genetic or acquired risk factor for POR * Previous poor ovarian response (POR) (≤3 oocytes with a conventional stimulation protocol using at least 150IU gonadotrophins per day) * Abnormal ovarian reserve test (i.e. AFC \< 5-7 or AMH \< 0.5-1.1ng/ml). Alternatively, two episodes of POR after maximal stimulation are sufficient to define a patient as poor responder in the absence of advanced maternal age or abnormal ORT. Exclusion Criteria: * Previous chemotherapy or pelvic irradiation * Polycystic ovarian syndrome or polycystic ovaries * On hormonal supplementation for any indication at the time of recruitment (e.g. estrogen, testosterone or DHEA)