MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study

Inclusion Criteria: * age 11 or older, * good health, * either gender * present with at least two active white spot lesions on his/her anterior teeth at the start of the study * have a moderate or high caries risk according to CAMBRA (Caries Management By Risk Assessment) rules * require at least 12 additional months of full fixed appliance therapy from the time they are recruited for the study * able to cooperate for treatment in the dental chair and follow at-home instructions * have an understanding of the study * willing to comply with all study procedures and protocols * patient participant is able to provide written informed consent in English; if the participant is a minor, the parent/guardian is able to provide written informed consent in English and the patient participant is able to provide written assent in English * patient participant or if a minor, the parent/guardian, is willing to sign the "Authorization for Release of Personal Health Information and Use of Personally Unidentified Study Data for Research" form; data will only be used for research * verifiable records of bonding with Transbond Plus Self-Etching Primer (3M Unitek, Monrovia, CA) and Transbond Light Cure Adhesive or similar products * verifiable records that "ProSeal" has not been applied at any time during the orthodontic treatment Exclusion Criteria: * untreated cavitated lesions * extensive composite fillings on buccal surfaces of front teeth/first bicuspids or more than one dental crown on …