11C- and 18F-Choline PET/MR Imaging for Prostate Cancer

Inclusion Criteria: * Age: Patients must be \>=18 years of age * Diagnosis: Patients must have a diagnosis of prostate cancer by histologic verification and a hypoechoic lesion seen on ultrasound. * Disease Status: Unfavorable intermediate to high-risk prostate cancer, per the Cancer of the Prostate Risk Assessment Score (CAPRA) (CAPRA 5-10) * Karnofsky Performance Status \>=70 * Metastatic workup: Whole Body Sodium Fluoride (NaF) PET/CT or 99mTc Bone Scan * Planned to undergo radical prostatectomy and extended pelvic lymph node dissection * Adequate bone marrow and organ function defined as follows: * Adequate bone marrow function: * Leukocytes \>= 3,000/microliter (mcL) * Absolute Neutrophil Count \>= 1,500/mcL * Platelets \>= 100,000/mcL * Adequate hepatic function: * Total bilirubin - within normal institutional limits * Aspartate aminotransferase (AST)/ serum glutamic-oxaloacetic transaminase (SGOT) \<= 2.5 X institutional upper limit of normal * Alanine aminotransferase (ALT)/serum glutamic-pyruvic transaminase (SGPT) \<= 2.5 X institutional upper limit of normal * Adequate renal function: * Creatinine - within normal institutional limits OR * Creatinine clearance \>= 60 mL/min/ 1.73m2 for patients with creatinine levels above institutional normal * Ability to understand a written informed consent document, and the willingness to sign it Exclusion Criteria: * Participation would significantly delay the scheduled standard of care therapy * Karnofsky performance status…