The Longitudinal Ovarian Reserve Study

Inclusion Criteria: * Females with the diagnosis of cancer schedules to be treated with chemotherapy and or radiation therapy. * Age between 15-45 years. * Post-menarchal. * Presence of a uterus and both ovaries. * Ability and willingness to comply with study protocol. * Have given written informed concent (or assent with parental consent in minors), prior to any study-related procedure, not part of normal medical care, with the understanding that consent may be withdrawn byt he patient at any time without prejudice to their future medical care. Exclusion Criteria: * Current pregnancy. * Lactation within the previous 3 months. * Any medical condition other than cancer, with in the judgment of the investigator is known to be associated with premature ovarian failure (such as Turner's Syndrome or Fragile X) or ovulatory dysfunction (such as thyroid disease, adrenal dysfunction, Cushing's syndrome, hyperprolactinemia, and polycystic ovarian syndrome).